Lipoprotein apheresis for refractory hyperlipidaemia: clinical indications and service requirements

نویسندگان

  • B. N. Datta
  • G. R. Thompson
چکیده

This paper describes lipoprotein apheresis, a crucial form of treatment for people with severe, statin-resistant hypercholesterolaemia (high cholesterol). The paper illustrates the merits and service specifications for a treatment that is little known, even among the medical fraternity. Apheresis is often the only effective treatment to help prolong the health and life of these very high cardiovascular risk patients. Apheresis is used less in the UK, when compared to similar countries such as the United States and Germany. Despite this, the procedure is increasingly under threat, as commissioners seek measures to reduce costs. However, for the patients described in this paper, apheresis remains an essential treatment that can often be the difference between life and death.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

LDL-apheresis and immunoadsorption: novel methods in the treatment of renal diseases refractory to conventional therapy.

Plasma exchange was used for many years as the method of extracorporeal removal of antibodies and/or immune complexes that may be involved in the pathogenesis of renal diseases. Recently low-density lipoprotein (LDL)-apheresis and immunoadsorption were also introduced into nephrological practice. LDL-apheresis, designed originally as a rescue treatment for refractory hyperlipidaemia, appeared a...

متن کامل

The expanding role of lipoprotein apheresis in the treatment of raised lipoprotein(a) in ischaemic heart disease and refractory angina

It is increasingly recognised that lipoprotein(a) [Lp(a)], an inherited, genetically-determined form of LDL-cholesterol, is an independent cardiovascular risk factor and predictor of adverse cardiovascular outcomes. Lp(a) is felt to increase cardiovascular risk via its pro-thrombotic effect and by enhancing intimal lipoprotein deposition. Lipoprotein apheresis is currently the most effective tr...

متن کامل

Indications for apheresis as an ultima ratio treatment of refractory hyperlipidemias

Lipid apheresis is at present well established in routine treatment of diverse hyperlipoproteinemias refractory to conventional dietary and medical regimens, especially in countries with high medical and socioeconomic standards. Severe familial hypercholesterolemia with atherosclerotic vessel disease involving the coronary arteries is the most frequent indication for lipid apheresis as well as ...

متن کامل

LDL-Apheresis: Technical and Clinical Aspects

The prognosis of patients suffering from severe hyperlipidemia, sometimes combined with elevated lipoprotein (a) levels, and coronary heart disease refractory to diet and lipid-lowering drugs is poor. For such patients, regular treatment with low-density lipoprotein (LDL) apheresis is the therapeutic option. Today, there are five different LDL-apheresis systems available: cascade filtration or ...

متن کامل

Selective whole blood lipoprotein apheresis to prevent pancreatitis in drug refractory hypertriglyceridemia.

CONTEXT Severe hypertriglyceridemia is a known cause of acute pancreatitis, and apheresis treatment, most commonly plasmapheresis, has been used to treat patients with drug refractory hypetriglyceridemia for more than 30 years. CASE REPORT We report a case in which a woman with Crohn's disease and type 2 diabetes mellitus developed recurrent episodes of acute pancreatitis due to extreme hyper...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012